I actually have a Wacom tablet too, but I don't find them convenient enough to replace the mouse. I don't like messing with the pen as I switch between the keyboard and the tablet. The other advantage of the mouse is that you make movements relative to its last position. This makes it more efficient to do repetitive tasks. The tablets also have a relative positioning mode, but I found it awkward and very unnatural. Maybe I just haven't used it enough, and just need to give it another go, but for now I'm happy with the mouse.

They're great for drawing though. It would have taken me a lot longer to make the Tangerine! icon without one.